Pyrimidine nucleosides
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphate | 1032-65-1 | 99.99% | 307.20 | 5 MG
2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite and a deoxynucleotide building block of DNA. It acts as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP, thereby supporting DNA biosynthesis.
- Endogenous metabolite
- Deoxynucleotide building block for DNA
- Substrate for UMP/CMP kinase
- Supports DNA biosynthesis
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphate-15N3 | 1032-65-1 | MFCD00006546 | 310.18 | 5 MG
2'-Deoxycytidine-5'-monophosphoric acid-15N3 is the 15N labeled form of 2'-Deoxycytidine-5'-monophosphoric acid, which is an endogenous metabolite.
- Target: endogenous metabolite
- Pathway: metabolic enzyme/protease
- Storage: solution, -20°C, protect from light, stable for 2 years
- Incorporates stable heavy isotopes for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Sigma Aldrich Fine Chemicals Biosciences Trifluorothymidine >=99% (HPLC) | 70-00-8 | MFCD00006534 | 100MG
Trifluorothymidine >=99% (HPLC) | Purity: >=99% (HPLC) | Mol Wt: 296.2 | 70-00-8 | MFCD00006534 | 100MG
Cayman Chemical 5-Bromo-2-deoxyurIdIn 500mg
A thymidine nucleoside derivative commonly used to identify proliferating cells; intraperitoneal injection of BrdU can be used in combination with neuronal markers to detect adult neurogenesis in animal models; commonly used as a marker of proliferation of cancer cells in vitro
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphate | 1032-65-1 | 99.6% | 307.20 | 250 MG
The product, 2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid), is an endogenous metabolite and a deoxynucleotide building block of DNA. It can serve as a substrate for UMP/CMP kinase to form dCDP upon phosphorylation to dCTP, thereby supporting DNA biosynthesis.
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: -20°C, protect from light, stored under nitrogen
- In solvent: -80°C for 6 months; -20°C for 1 month (protect from light, stored under nitrogen)
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphoric acid-¹³C₉ (dilithium) | 99.5% | 328.00 | 1 MG
This product is 2'-Deoxycytidine-5'-monophosphate-¹³C₉ (dilithium), an isotopically labeled deoxycytidine monophosphate. It is provided as a colorless to light yellow solution at a concentration of 1 mg (70 mM in 43.55 μL Tris HCl/H₂O buffer pH=7.5). The compound is suitable for research applications requiring a high purity labeled standard.
- Isotopically labeled with ¹³C₉
- High purity of 99.5% (HPLC)
- Isotopic enrichment of 98.9%
- Provided in a solution format
- Recommended for storage at -20°C for up to 2 years
Cambridge Isotope Laboratories 2'-DEOXYURIDINE:AMMONIUM SALT 90% CHEMICAL PURITY (13C9, 98-99%; 15N2, 98-99%) (IN SOLN), 100 UMOL
2'-DEOXYURIDINE:AMMONIUM SALT 90% CHEMICAL PURITY (13C9, 98-99%; 15N2, 98-99%) (IN SOLN), 100 UMOL
Cambridge Isotope Laboratories 5-Fluoro-2-deoxycytidine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 95% 100 umol
5-Fluoro-2-deoxycytidine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 95% 100 umol
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 98.0% | 500 MG
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Inhibits biological effects of bromodeoxyuridine (Brdu).
- Essential for nucleic acid synthesis.
- Used in cancer research.
- Target: endogenous metabolite.
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 100.0% | 5 G
2'-Deoxycytidine, a deoxyribonucleoside, can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Deoxyribonucleoside
- Inhibits biological effects of bromodeoxyuridine (Brdu)
- Essential for the synthesis of nucleic acids
- Can be used for cancer research
- Inhibits tumor growth in mice
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 99.95% | 1 G
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Inhibits biological effects of Brdu.
- Essential for nucleic acid synthesis.
- Used in cancer research.
- Inhibits tumor growth in vivo.
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 99.95% | 1 ML
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Inhibits biological effects of Bromodeoxyuridine (Brdu)
- Essential for nucleic acid synthesis
- Can be used for cancer research
- Intended for research use only
Medchemexpress LLC KTX-951 | 2573298-36-7 | 99.6% | 850.95 | 1 MG
KTX-951 is an orally active PROTAC degrader targeting IRAK4 and IMiD (Ikaros/Aiolos) substrates. It exhibits a Kd of 3.5 nM for IRAK4, with DC50 values of 13 nM, 14 nM, and 13 nM for IRAK4, Ikaros, and Aiolos, respectively. This compound also shows an IC50 of 35 nM for OCl-Ly10 CTG and demonstrates antitumor activity.
- Orally active PROTAC degrader
- Targets IRAK4 and IMiD (Ikaros/Aiolos) substrates
- Kd of 3.5 nM for IRAK4
- Molecular weight: 850.95
- Formula: C46H52F2N8O6
- Appearance: Solid, light yellow to yellow
- Purity: 99.60%
- Soluble in DMSO at 50 mg/mL (58.76 mM)
- Oral bioavailability in rats: 22% at 10 mg/kg
- Oral bioavailability in dogs: 57% at 10 mg/kg
Medchemexpress LLC 2'-Deoxyuridine | 951-78-0 | 99.98% | 500 MG
2'-Deoxyuridine is a brain-penetrant pyrimidines nucleotide associated with nervous system diseases. It can increase chromosome breakage and decrease thymidylate synthetase activity. This product serves as a precursor in the synthesis of Edoxudine and is an analogue of 5-ethynyl-2'-deoxyuridine. It has shown promise in Alzheimer's disease (AD) research by reducing microglial activation and improving oxidative stress damage through modulation of glycolytic metabolism on Aβ25-35-induced brain injury.
- Associated with nervous system diseases.
- Increases chromosome breakage.
- Decreases thymidylate synthetase activity.
- Precursor in the synthesis of edoxudine.
- Analogue of 5-ethynyl-2'-deoxyuridine.
- Reduces microglial activation.
- Improves oxidative stress damage.
Sigma Aldrich Fine Chemicals Biosciences 5-Bromo-2′-deoxyuridine | 59-14-3 | MFCD00006529 | 500mg
5-Bromo-2′-deoxyuridine | Purity: ≥99% (HPLC) | MW:307.1 | 59-14-3 | MFCD00006529 | 500mg